Inactivation and Heat Stabilization of Poliovirus by 2-Thiouracil
نویسندگان
چکیده
منابع مشابه
Inactivation and heat stabilization of poliovirus by 2-thiouracil.
Treatment of poliovirus Type I with 10(-3)m 2-thiouracil (2-TU) resulted in the inactivation of greater than 90% of the virus infectivity and stabilization of approximately 50% of the residual virus to heat inactivation. These effects were due to a reaction with the protein moiety of the virus and could be blocked by pre-treatment of the virus with l-cystine or of the drug with cysteine. Both i...
متن کاملHeat inactivation of poliovirus in wastewater sludge.
The effect of raw and anaerobically digested sludge on heat inactivation of poliovirus was investigated. Raw sludge was found to be very protective of poliovirus plaque-forming ability at all temperatures studied, but digested sludge had variable effects that were highly dependent upon the experimental conditions. In low concentrations and at relatively low inactivation temperatures, digested s...
متن کاملMechanisms of inactivation of poliovirus by chlorine dioxide and iodine.
Chlorine dioxide and iodine inactivated poliovirus more efficiently at pH 10.0 than at pH 6.0. Sedimentation analyses of viruses inactivated by chlorine dioxide and iodine at pH 10.9 showed that viral RNA separated from the capsids, resulting in the conversion of virions from 156S structures to 80S particles. The RNAs release from both chlorine dioxide- and iodine-inactivated viruses cosediment...
متن کاملEffect of formaldehyde inactivation on poliovirus 1 2
2 Thomas Wilton, Glynis Dunn, David Eastwood, Philip D. Minor and Javier Martin 3 4 Division of Virology and Biotherapeutics, National Institute for Biological Standards and 5 Control, Potters Bar, Hertfordshire, United Kingdom. 6 7 Running title: Inactivated Polio Vaccine 8 Abstract and Importance: 328 words 9 Text: 4910 words 10 11 12 13 14 15 16 17 # Corresponding author’s mailing address: T...
متن کاملStudy of the Heat-Treated Human Albumin Stabilization by Caprylate and Acetyltryptophanate
Sodium salt of N-acetyl-DL-tryptophan (AT) and octanoic acid (caprylic acid CA) individually and in combination were studied as thermal stabilizer with different concentrations in heat treatment of human albumin solution. HPLC protein profiles before pasteurization of albumin showed less than 1% polymer. In free stabilizer albumin solution during pasteurization visible clot was formed. But by u...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 1967
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.1.4.653-658.1967